MEGAN6 Download Page

This is the official download site for the most recent version of MEGAN 6. The Community Edition of the paper is described here: Huson et al,, (2016), PLoS Computational Biology

Please post questions and bug reports to the community website.

MEGAN6 Community Edition installers:

This is open source.

MEGAN_Community_macos_6_25_10.dmg
MEGAN_Community_unix_6_25_10.sh
MEGAN_Community_unix_ARM_6_25_10.sh
MEGAN_Community_windows-x64_6_25_10.exe

The following file maps NCBI-nr accessions to taxonomic and functional classes (NCBI, GTDB, EC, eggNOG, InterPro2GO, SEED), unzip before use:

megan-map-Feb2022.db.zip

The following file maps genomic DNA accessions to taxonomic classes, unzip before use:

megan-nucl-Feb2022.db.zip

MEGAN6 Ultimate Edition installers (require license key):

MEGAN6 Ultimate Edition is licensed by Computomics GmbH. Apply for a trial license here. The Ultimate Edition comes with the latest KEGG classification and pathway files.

MEGAN_Ultimate_macos_6_25_10.dmg
MEGAN_Ultimate_unix_6_25_10.sh
MEGAN_Ultimate_unix_ARM_6_25_10.sh
MEGAN_Ultimate_windows-x64_6_25_10.exe

The following mapping file only works with MEGAN Ultimate Edition. It contains KEGG, as well as NCBI, GTDB, eggNOG, InterPro2GO and SEED, unzip before use:

megan-map-Feb2022-ue.db.zip

Mapping file for working with the SILVA SSU (and/or LSU) database:

SSURef_132_Nr99_tax_silva_to_NCBI_synonyms.map.gz
LSURef_132_tax_silva_to_NCBI_synonyms.map.gz
SSURef_NR99_128_tax_silva_to_NCBI_synonyms.map.gz
Provide this file to MEGAN as a synonyms mapping file when importing alignments against the Silva database. No need to decompress before use.

Expanded mapping files:

Very large mapping files to be used with special purpose protein databases:

megan-map-Jul2020-2-X.db.zip
megan-map-Jul2020-2-X-ue.db.zip

Use DIAMOND+MEGAN with AnnoTree:

Download AnnoTree proteins and an associated MEGAN mapping database:

AnnoTree for MEGAN

Additional files:

Release notes
Manual
MeganServer Manual
md5sums.txt

Old files:

Old mapping files and installers